2001-20022003-20042005-20062007-20082009-2010p Value
Baseline DAS28 (mean (SD))
 MTX mono5.17 (1.26)5.06 (1.33)4.85 (1.29)4.62 (1.39)4.75 (1.30)<0.001
 TNFi+MTX5.88 (1.23)5.25 (1.23)5.21 (1.25)4.87 (1.46)4.64 (1.41)<0.001
Baseline 28-SJC (mean (SD))
 MTX mono9 (6)8 (6)7 (6)6 (5)6 (5)<0.001
 TNFi+MTX10 (5)9 (6)8 (5)6 (5)6 (4)<0.001
Baseline CRP, mg/l (median, (IQR))
 MTX mono22 (7-35)13 (5-31)10 (5-25)8 (3-20)7 (3-21)<0.001
 TNFi+MTX27 (12-54)19 (8-37)12 (5-30)9 (5-22)7 (3-20)<0.001
EULAR good response 6 months (% (n))
 MTX mono25.7 (59)35.5 (105)37.8 (90)33.5 (65)39.2 (40)0.03
 TNFi+MTX29.3 (17)44.6 (50)46.5 (46)43.6 (34)38.0 (19)0.47
DAS28 remission 6 months (% (n))
 MTX mono17.8 (43)29.2 (95)33.7 (89)38.1 (80)37.6 (44)<0.001
 TNFi+MTX16.9 (10)29.3 (36)34.5 (38)31.4 (27)46.3 (25)0.003