SNP | Gene | Risk allele | Sample cohort | RAF | OR (95% CI) | PComb | Meta Q p value | |
---|---|---|---|---|---|---|---|---|
Case | Control | |||||||
rs35656932 | ZNF193 | T | Toronto | 0.118 | 0.075 | 1.66 (1.38 to 1.99) | 3.82×10−8 | |
Halifax | 0.119 | 0.083 | 1.48 (1.11 to 1.99) | 8.31×10−3 | ||||
USA | 0.088 | 0.070 | 1.29 (1.02 to 1.62) | 0.032 | ||||
Combined* | 0.109 | 0.074 | 1.50 (1.32 to 1.71) | 4.24×10−10 | 0.23 | |||
rs13208096 | NKAPL | G | Toronto | 0.115 | 0.075 | 1.61 (1.34 to 1.94) | 3.69×10−7 | |
Halifax | 0.116 | 0.081 | 1.48 (1.10 to 1.99) | 8.75×10−3 | ||||
USA | 0.086 | 0.068 | 1.30 (1.03 to 1.63) | 0.028 | ||||
Combined | 0.107 | 0.073 | 1.48 (1.32 to 1.69) | 2.44×10−9 | 0.35 |
*Combined p values for association (PComb) were performed using Cochran-Mantel Haenszel tests stratifying by centre. The Cochran Q tests for heterogeneity in the effect among studies.
NKAPL, NF-κB activating protein-like; RAF: risk allele frequency.