Shared genetic determinants (p≤1.0 × 10−3) between osteoarthritis and BMI
| SNP | Chromosome | Allele | Osteoarthritis p value | Osteoarthritis OR | 95% CI | BMI p value | BMI z score | Nearest gene |
|---|---|---|---|---|---|---|---|---|
| rs4856346 | 3 | T | 6.1×10−4 | 1.14 | 1.05 to 1.22 | 7.1×10−4 | 3.48 | GBE1 |
| rs7828042 | 8 | G | 1.1×10−4 | 1.14 | 1.07 to 1.22 | 2.1×10−4 | 4.05 | SLURP1 |
| rs7203219 | 16 | T | 3.5×10−4 | 1.19 | 1.08 to 1.31 | 3.4×10−4 | 3.87 | GPR139 |
| rs12149832 | 16 | A | 2.8×10−4 | 1.12 | 1.06 to 1.20 | 1.9×10−16 | 8.47 | FTO |
BMI, body mass index; SNP, single nucleotide polymorphism.