Table 2

Odds Ratios (OR) from robust logistic regression analysis testing the association between biomarker levels (baseline and changes from baseline to week 4) and clinical endpoints with at least one significant association at week 14 in the golimumab group

	ACR20		DAS28		PASI75
Biomarker	OR	p Value	OR	p Value	OR	p Value
Baseline
Adiponectin	1.681	NS	2.296	0.019	1.969	0.035
Apolipoprotein CIII	0.865	NS	1.459	NS	2.397	0.048
ENRAGE	1.133	NS	2.455	0.006	0.717	NS
IgA	1.013	NS	1.849	0.023	1.279	NS
IGF-1	1.234	NS	1.668	NS	0.272	0.015
IL-16	0.858	NS	2.330	0.028	1.063	NS
Insulin	0.803	NS	0.706	0.018	0.876	NS
Myeloperoxidase	1.323	NS	1.743	0.019	0.720	NS
PAP	2.528	0.034	2.761	0.021	0.927	NS
SGOT	0.536	NS	0.274	0.001	1.471	NS
VEGF	1.665	0.042	2.338	0.008	1.133	NS
Pyridinoline	0.198	0.008	0.344	NS	0.777	NS
MMP-3	1.115	NS	1.264	NS	0.509	NS
Change from baseline to week 4
CRP	0.708	0.038	0.700	NS	0.851	NS
Cancer antigen 125	0.286	0.034	0.293	0.046	0.929	NS
Carcinoembryonic Antigen	0.054	0.024	0.341	NS	0.461	NS
CD40	0.516	NS	0.265	0.040	2.171	NS
CD40 ligand	0.773	NS	0.558	0.027	1.100	NS
ENRAGE	0.589	0.029	0.622	NS	1.319	NS
ICAM-1	0.387	NS	0.178	0.028	2.280	NS
IL-16	0.305	0.047	0.191	0.016	1.224	NS
MDC	0.118	0.009	0.324	NS	0.233	NS
MIP-1α	0.976	NS	0.319	0.015	1.033	NS
MIP-1β	0.544	NS	0.127	0.009	0.899	NS
Myeloperoxidase	0.806	NS	0.589	0.014	1.077	NS
PSA-free	0.343	NS	0.167	0.025	0.604	NS
PAP	0.220	0.009	0.144	0.003	1.243	NS
SGOT	1.150	NS	2.251	0.040	0.459	0.044
TNF receptor II	0.158	NS	0.090	0.032	0.500	NS
VEGF	0.395	NS	0.196	0.009	1.836	NS
TNFα serum	0.592	NS	0.400	NS	0.039	<0.001
ICAM-1	0.055	0.044	0.235	NS	0.428	NS

Values were significant if they were p<0.05.
ACR20, American College of Rheumatology 20% improvement response; CRP, C-reactive protein; DAS28, disease activity score in 28 joints; ICAM, intercellular adhesion molecule; IL, interleukin; IG, immunoglobulin; MDC, monocyte/macrophage-derived chemokine; MIP-1, macrophage inflammatory protein 1; MMP, matrix metalloproteinase; NS, not significant; PAP, prostatic acid phosphatase; PSA, prostate-specific antigen; PASI75, 75% improvement in the psoriasis area and severity index score; SGOT, serum glutamic oxaloacetic transaminase; TNF, tumour necrosis factor; VEGF, vascular endothelial growth factor.