Predictive validity of different remission definitions for no functional disability and absence of PDPS over 1 year
| In remission | Not in remission | LR+ (95% CI) | p Value | |
|---|---|---|---|---|
| Functional outcome | ||||
| DAS<1.6 | 45/62 | 29/72 | 2.14 (1.37 to 3.33) | <0.001 |
| DAS28<2.6 | 40/50 | 34/84 | 3.24 (1.77 to 5.93) | <0.0001 |
| DAS28<2.0 | 17/19 | 57/115 | 6.89 (1.65 to 28.6) | 0.001 |
| SDAI≤3.3 | 18/21 | 56/113 | 4.86 (1.50 to 15.73) | 0.002 |
| ACR/EULAR | 14/16 | 60/118 | 5.67 (1.34 to 24.00) | 0.005 |
| Ultrasonographic outcome | ||||
| DAS<1.6 | 25/58 | 27/66 | 1.04 (0.71 to 1.53) | 0.80 |
| DAS28<2.6 | 24/44 | 28/80 | 1.66 (1.03 to 2.66) | 0.03 |
| DAS28<2.0 | 11/17 | 41/107 | 2.53 (1.00 to 6.42) | 0.04 |
| SDAI≤3.3 | 14/17 | 38/107 | 6.46 (1.95 to 21.34) | 0.0003 |
| ACR/EULAR | 11/14 | 41/110 | 5.07 (1.49 to 17.29) | 0.003 |
Functional outcome: HAQ persistently 0.5 or less during follow-up and a change in HAQ of 0 or less during follow up.
Ultrasonographic outcome: absence of PDPS throughout the follow-up. In the fractions, numerators refer to the number of patients achieving the outcome, denominators refer to the number of patients in that category (remission or not remission).
ACR/EULAR, American College of Rheumatology/European League Against Rheumatism; DAS, disease activity score; HAQ, health assessment questionnaire; LR+, positive likelihood ratio; PDPS, power Doppler-positive synovitis; SDAI, simplified disease activity index.