Table 2

Incidence rates of serious adverse events of interest*

Rheumatoid arthritisJuvenile idiopathic arthritisAnkylosing spondylitisPsoriatic arthritisPsoriasisCrohn's disease
N14 109212168483730103606
Exposure, PYs23 942.6604.91985.6997.55061.84138.0
Serious infections4.62.01.42.81.76.7
Active tuberculosis0.3000.20.1<0.1
Opportunistic infections<0.10000<0.1
Demyelinating disorder<0.10<0.1000.1
Lupus-like syndrome<0.100.100<0.1
CHF0.200.10<0.10
New onset/worsening of psoriasis<0.10<0.10.1<0.1<0.1
Malignancies excluding lymphoma and NMSC0.900.20.20.60.5
Lymphoma0.10<0.10.2<0.1<0.1
NMSC†0.200.30.10.1<0.1
Melanoma<0.10<0.100.20
Any AE leading to death0.80<0.10.30.20.1

  • ↵* Rates in events/100 PYs.

  • ↵† Only serious NMSC events.

  • AE, adverse event; CHF, congestive heart failure; NMSC, non-melanoma skin cancer; PYs, patient-years.