HLA-A allele frequency in the RA patients
| MI-ILD (+) | MI-ILD (−) | p | OR | Pc | 95% CI | |
|---|---|---|---|---|---|---|
| A*01:01 | 2 (1.82) | 9 (0.63) | 0.1849 | 2.90 | NS | |
| A*02:01 | 14 (12.73) | 163 (11.50) | 0.6448 | 1.12 | NS | |
| A*02:03 | 0 (0.00) | 2 (0.14) | 1.0000 | 2.56 | NS | |
| A*02:06 | 11 (10.00) | 139 (9.80) | 0.8690 | 1.02 | NS | |
| A*02:07 | 2 (1.82) | 54 (3.81) | 0.4281 | 0.47 | NS | |
| A*02:10 | 0 (0.00) | 12 (0.85) | 1.0000 | 0.51 | NS | |
| A*02:73 | 0 (0.00) | 1 (0.07) | 1.0000 | 4.28 | NS | |
| A*03:01 | 1 (0.91) | 5 (0.35) | 0.3618 | 2.59 | NS | |
| A*03:02 | 0 (0.00) | 2 (0.14) | 1.0000 | 2.56 | NS | |
| A*11:01 | 8 (7.27) | 150 (10.58) | 0.3306 | 0.66 | NS | |
| A*11:02 | 0 (0.00) | 3 (0.21) | 1.0000 | 1.83 | NS | |
| A*24:02 | 33 (30.00) | 514 (36.25) | 0.2155 | 0.75 | NS | |
| A*24:04 | 0 (0.00) | 1 (0.07) | 1.0000 | 4.28 | NS | |
| A*24:08 | 0 (0.00) | 1 (0.07) | 1.0000 | 4.28 | NS | |
| A*24:20 | 0 (0.00) | 11 (0.78) | 1.0000 | 0.55 | NS | |
| A*24:25 | 0 (0.00) | 1 (0.07) | 1.0000 | 4.28 | NS | |
| A*26:01 | 5 (4.55) | 93 (6.56) | 0.5442 | 0.68 | NS | |
| A*26:02 | 2 (1.82) | 27 (1.90) | 1.0000 | 0.95 | NS | |
| A*26:03 | 0 (0.00) | 34 (2.40) | 0.1686 | 0.18 | NS | |
| A*26:05 | 0 (0.00) | 2 (0.14) | 1.0000 | 2.56 | NS | |
| A*30:01 | 0 (0.00) | 1 (0.07) | 1.0000 | 4.28 | NS | |
| A*31:01 | 23 (20.91) | 116 (8.18) | 8.06×10−5 | 2.97 | 1.93×10−3 | (1.80 to4.88) |
| A*32:01 | 0 (0.00) | 1 (0.07) | 1.0000 | 4.28 | NS | |
| A*33:03 | 9 (8.18) | 76 (5.36) | 0.1979 | 1.57 | NS | |
| A19 (A*29–*33, *74) | 32 (29.09) | 194 (13.68) | 6.47×10−5 | 2.59 | (1.67 to 4.01) |
Allele frequencies are shown in parenthesis (%). Significance of associations was tested by Fisher's exact test using 2×2 contingency tables. Adjustment for multiple comparisons was performed using the Bonferroni method. Pc values were calculated by multiplying the p value by the number of alleles tested (24 alleles for HLA-A).
HLA, human leukocyte antigen; MI-ILD(+), RA with MI-ILD; MI-ILD(−), RA without MI-ILD; NS, not significant; Pc, corrected p value; RA, rheumatoid arthritis.