Age and multivariate-adjusted RR for the association of adiposity measurements with risk of psoriatic arthritis among all participants*
| Cases | Person-years | Age-adjusted RR (95% CI) | Multivariate-adjusted RR† (95% CI) | |
|---|---|---|---|---|
| Updated BMI (kg/m2) | 146 | 1 231 693 | ||
| <25.0 | 40 | 703 190 | 1.00 | 1.00 |
| 25.0–29.9 | 35 | 297 149 | 1.88 (1.19 to 2.96) | 1.83 (1.15 to 2.89) |
| 30.0–34.9 | 28 | 133 146 | 3.22 (1.98 to 5.26) | 3.12 (1.90 to 5.11) |
| ≥35.0 | 43 | 98 208 | 6.60 (4.26 to 10.23) | 6.46 (4.11 to 10.16) |
| p for trend | <0.0001 | <0.0001 | ||
| BMI at age 18 years (kg/m2) | 145 | 1 222 076 | ||
| <21.0 | 67 | 701 559 | 1.00 (0.64 to 1.58) | 1.04 (0.66 to 1.64) |
| 21.0–22.9 | 26 | 272 700 | 1.00 | 1.00 |
| 23.0–24.9 | 24 | 125 453 | 2.01 (1.15 to 3.50) | 1.93 (1.11 to 3.37) |
| 25.0–29.9 | 17 | 93 857 | 1.88 (1.02 to 3.46) | 1.74 (0.94 to 3.21) |
| ≥30.0 | 11 | 28 508 | 4.07 (2.01 to 8.24) | 3.55 (1.75 to 7.23) |
| p for trend | <0.0001 | <0.0001 | ||
| Weight change from age 18 years (lb) | 145 | 1 222 076 | ||
| Loss or increase of <20.0 | 32 | 563 364 | 1.00 | 1.00 |
| Increase of 20.0–49.9 | 45 | 435 087 | 1.68 (1.06 to 2.65) | 1.72 (1.09 to 2.72) |
| Increase of 50.0–99.9 | 50 | 191 981 | 3.88 (2.46 to 6.13) | 3.67 (2.31 to 5.84) |
| Increase of ≥100.0 | 18 | 31 645 | 8.09 (4.48 to 14.64) | 7.00 (3.78 to 12.96) |
| p for trend | <0.0001 | <0.0001 | ||
| Waist circumference (inches) | 72 | 599 200 | ||
| Tertile 1, <28.0 | 7 | 168 183 | 1.00 | 1.00 |
| Tertile 2, 28.0–31.9 | 17 | 227 235 | 1.72 (0.71 to 4.16) | 1.65 (0.68 to 4.00) |
| Tertile 3, ≥32.0 | 48 | 203 782 | 5.05 (2.28 to 11.20) | 4.82 (2.15 to 10.83) |
| p for trend | <0.0001 | <0.0001 | ||
| Hip circumference (inches) | 70 | 597 544 | ||
| Tertile 1, <38.0 | 13 | 233 613 | 1.00 | 1.00 |
| Tertile 2, 38.0–40.9 | 13 | 187 362 | 1.18 (0.55 to 2.56) | 1.25 (0.58 to 2.72) |
| Tertile 3, ≥41.0 | 44 | 176 569 | 4.02 (2.16 to 7.51) | 4.32 (2.27 to 8.24) |
| p for trend | <0.0001 | <0.0001 | ||
| Waist–hip ratio | 70 | 596 835 | ||
| Tertile 1, <0.744 | 12 | 199 028 | 1.00 | 1.00 |
| Tertile 2, 0.744–0.800 | 20 | 207 096 | 1.58 (0.77 to 3.23) | 1.49 (0.73 to 3.06) |
| Tertile 3, >0.800 | 38 | 190 712 | 3.12 (1.63 to 5.98) | 2.84 (1.48 to 5.48) |
| p for trend | 0.0002 | 0.0006 |
↵* Psoriasis cases with only skin phenotypes were excluded during the follow-up.
↵† Adjusted for age (continuous variable), smoking (never, past, current with 1–14, 15–24, or ≥25 cigarettes/day), alcohol drinking (no, <4.9, 5.0–9.9, 10–14.9, 15–29.9 or ≥30.0 g/day), vigorous physical activity (metabolic equivalent hours/week, in quintile), and height (inches, for the analysis of waist circumference, hip circumference and waist–hip ratio), and weight at 18 years (for the analysis of weight change from 18 years).
BMI, body mass index.