UK JIA oligoarthritis and RF-negative polyarthritis cases (n=798) | US JIA oligoarthritis and RF-negative polyarthritis cases (n=813) | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP | Chr | Position | Gene | Minor allele | Major allele | MAF cases | MAF controls | pTREND | OR (95% CI) | MAF cases | MAF controls | pTREND | OR (95% CI) | Combined meta-analysis p value | OR (95% CI) | Breslow–Day p value |
rs4272626 | 1 | 116149950 | NHLH2 | T | C | 0.34 | 0.36 | 0.07 | 0.90 (0.81 to 1.01) | 0.36 | 0.37 | 0.33 | 0.95 (0.84 to 1.06) | 0.05 | 0.92 (0.85 to 1.0) | 0.55 |
rs11586238 | 1 | 117064661 | CD2 | G | C | 0.26 | 0.24 | 0.10 | 1.11 (0.98 to 1.25) | 0.22 | 0.24 | 0.39 | 0.94 (0.83 to 1.08) | 0.56 | 1.03 (0.94 to 1.12) | 0.08 |
rs1773560 | 1 | 165688387 | CD247 | G | A | 0.39 | 0.42 | 0.008 | 0.86 (0.77 to 0.96) | 0.38 | 0.41 | 0.01 | 0.87 (0.78 to 0.97) | 2.8×10−4 | 0.86 (0.8 to 0.92) | 0.93 |
rs10919563 | 1 | 196967065 | PTPRC | A | G | 0.09 | 0.13 | 4.2×10−6 | 0.65 (0.54 to 0.78) | 0.14 | 0.12 | 0.08 | 1.16 (0.98 to 1.36) | 0.04 | 0.88 (0.78 to 0.99) | 3.3×10−6 |
rs874040 | 4 | 25717295 | RBPJ | G | C | 0.33 | 0.30 | 0.04 | 1.14 (1.01 to 1.28) | 0.31 | 0.30 | 0.59 | 1.03 (0.92 to 1.16) | 0.07 | 1.08 (0.99 to 1.18) | 0.27 |
rs2736340 | 8 | 11381382 | BLK | T | C | 0.28 | 0.24 | 0.007 | 1.19 (1.05 to 1.36) | 0.26 | 0.26 | 0.99 | 1.00 (0.88 to 1.13) | 0.06 | 1.09 (1.0 to 1.19) | 0.05 |
rs706778 | 10 | 6138955 | IL2RA | T | C | 0.45 | 0.40 | 0.002 | 1.20 (1.07 to 1.35 | 0.46 | 0.40 | 0.0002 | 1.24 (1.11 to 1.38) | 9.5×10−7 | 1.22 (1.13 to 1.32) | 0.74 |
rs2872507 | 17 | 35294289 | ORMDL3 | A | G | 0.53 | 0.48 | 0.001 | 1.22 (1.08 to 1.37) | 0.46 | 0.46 | 0.93 | 0.99 (0.89 to 1.11) | 0.03 | 1.09 (1.01 to 1.18) | 0.01 |
rs7234029 | 18 | 12867060 | PTPN2 | G | A | 0.20 | 0.16 | 9.3×10−6 | 1.35 (1.18 to 1.54) | 0.23 | 0.16 | 1.3×10−8 | 1.48 (1.29 to 1.69) | 8.1×10−13 | 1.41 (1.28 to 1.55) | 0.33 |
Breslow–Day p value is a measure of whether there is significant difference in the OR in the two cohorts.
Chr, chromosome; JIA, juvenile idiopathic arthritis; MAF, minor allele frequency; pTREND, p value for the Armitage test for trend as generated in PLINK; SNP, single-nucleotide polymorphism.