Comparison of different remission and low disease activity definitions to the ACR/EULAR definition of remission and their effect on work productivity and health assessment (n=721)
| ACR/EULAR remission (n=127) | DAS28 remission (n=147) | p | DAS28 low disease activity (n=125) | p | CDAI low disease activity (n=246) | p | |
|---|---|---|---|---|---|---|---|
| SF12 PCS | 45.8±9.4 | 38.4±9.1 | <0.0001 | 34.4±8.9 | <0.0001 | 36.76±9.3 | <0.0001 |
| MCS | 52.4±8.1 | 48.8±10.0 | 0.005 | 47.0±9.4 | <0.0001 | 48.0±9.9 | <0.0001 |
| WPAI (%) Act imp | 13.7±20.7 | 29.4±26.3 | <0.0001 | 42.6±24.2 | <0.0001 | 35.1±26.6 | <0.0001 |
| Time missed | 0.6±3.2 | 9.6±23.7 | 0.01 | 2.7±11.4 | 0.143 | 5.9±17.8 | 0.011 |
| Imp working | 9.4±18.5 | 20.0±21.9 | <0.0001 | 29.3±25.2 | <0.0001 | 24.5±22.8 | <0.0001 |
| Overall Imp | 10.1±18.7 | 25.8±29.4 | <0.0001 | 31.5±26.6 | <0.0001 | 28.0±26.8 | <0.0001 |
| RAPID3 | 1.0±1.0 | 1.9±1.7 | <0.0001 | 3.4±1.8 | <0.0001 | 3.0±1.8 | <0.0001 |
Remission definitions were individually applied to all subjects and those fulfilling ACR/EULAR remission are removed from other categories so same subjects are not represented in multiple groups. Majority of those in CDAI remission fulfilled ACR/EULAR remission (106/109) so comparisons were not made. RACER: Rheumatoid Arthritis Comparative Effectiveness Research ACR/EULAR=American College of Rheumatology/European League Against Rheumatism; SF12: short form-12; PCS: physical component score; MCS: mental component score; WPAI: Work Productivity and Activity Impairment; RAPID3: Routine Assessment of Patient Index Data-3.