ASAS 20 at week 14 | BASFI change from baseline to week 14 | BASDAI change from baseline to week 14 | ||||
---|---|---|---|---|---|---|
Biomarker | OR | p Value | OR | p Value | OR | p Value |
Baseline | ||||||
Apolipoprotein C3 | 0.35 | 0.019 | 0.41 | 0.036 | 0.69 | NS |
Deoxypyridinoline | 6.49 | 0.033 | 4.15 | NS | 7.48 | 0.017 |
Epithelial neutrophil activating peptide-78 | 2.00 | NS | 2.44 | 0.031 | 3.12 | 0.010 |
Haptoglobin | 1.70 | 0.046 | 1.72 | 0.040 | 1.70 | NS |
Insulin | 0.63 | 0.009 | 0.66 | 0.013 | 0.77 | NS |
Interleukin 6 | 1.80 | 0.017 | 1.47 | NS | 1.72 | 0.014 |
Leptin | 0.64 | 0.041 | 0.62 | 0.027 | 0.79 | NS |
N-terminal propeptide of type 1 collagen | 5.94 | 0.004 | 4.20 | 0.011 | 2.47 | 0.049 |
Osteocalcin | 10.88 | 0.001 | 10.14 | 0.002 | 3.13 | 0.033 |
Change from baseline to week 4 | ||||||
α-1 Antitrypsin | 0.04 | 0.018 | 0.09 | 0.039 | 0.09 | 0.032 |
C-reactive protein | 0.72 | 0.025 | 0.69 | 0.010 | 0.74 | 0.025 |
Complement 3 | 0.02 | 0.004 | 0.02 | 0.003 | 0.01 | 0.001 |
Haptoglobin | 0.20 | 0.007 | 0.23 | 0.006 | 0.17 | 0.002 |
Interleukin 6 | 0.36 | 0.003 | 0.52 | 0.013 | 0.43 | 0.002 |
Serum amyloid P | 0.30 | NS | 0.13 | 0.013 | 0.21 | 0.036 |
Thyroxine binding globulin | 0.33 | NS | 0.07 | 0.027 | 0.09 | 0.032 |
Only biomarkers with significant associations across multiple endpoints are shown.
OR represents the increased odds of clinical response for a 1 unit change on the log2 scale or a doubling on the linear scale.
ASAS 20, at least 20% improvement in Assessment in SpondyloArthritis international Society response criteria; Bath ankylosing spondylitis disease activity index; BASFI, Bath ankylosing spondylitis functional index; NS, not significant (p>0.05).