Cohort name | |||||||
---|---|---|---|---|---|---|---|
Genetics of Osteoarthritis and Lifestyle | Hertfordshire Cohort Study | Nottingham Case-Control Study | Chingford Study | TwinsUK Study | Clearwater Osteoarthritis Study | Tasmanian Older Adult Cohort | |
Cohort acronym | GOAL | HCS | Nott | Chingford | TwinsUK | COS | TASOAC |
Country of origin | UK | UK | UK | UK | UK | USA | Australia |
Knee OA | |||||||
Symptomatic | n=1199 | n=86 | n=1703 | n=68 | n=45 | n=83 | n=86 |
Age (years), mean (SD) | 68.4 (7.2) | 65.3 (2.8) | 68.7 (8.9) | 65.7 (5.8) | 57.5 (7.2) | 65.6 (8.3) | 65.0 (7.2) |
Female (%) | 46.9 | 44.3 | 55.3 | 100 | 100 | 66.7 | 58.50 |
BMI (kg/m2), mean (SD) | 31.2 (5.4) | 29.7 (5.4) | 29.7 (5.4) | 26.7 (3.4) | 27.9(4.5) | 29.1 (5.1) | 31.3 (6.3) |
K/L≥3 (%) | 89.7 | 38.6 | 80.8 | 44.1 | 29.0 | 32.9 | 42.6 |
TKR (%) | 94.8 | 9.3 | 90.3 | 23.5 | 26.7 | 24 | 0 |
TRPV1 585 Ile–Ile (%) | 11.4 | 12.8 | 12.9 | 8.8 | 9.3 | 15.5 | 12.6 |
MAF (%) | 35.1 | 37.2 | 36.9 | 38.2 | 31.4 | 33.8 | 35.1 |
Asymptomatic | n=376 | n=44 | n=0 | n=216 | n=235 | n=91 | n=136 |
Age (years), mean (SD) | 69.0 (6.7) | 65.2 (6.4) | N/A | 65.7 (5.9) | 58.1 (7.8) | 64.0 (9.8) | 65.8 (7.6) |
Female (%) | 43.9 | 31.8 | N/A | 100 | 100 | 54.6 | 43.80 |
BMI (kg/m2), mean (SD) | 28.9 (4.9) | 28.4 (4.0) | N/A | 26.2 (4.4) | 26.7 (4.9) | 26.1 (4.7) | 28.1 (4.3) |
K/L≥3 (%) | 49.5 | 15.9 | N/A | 26.4 | 34.0 | 21.7 | 24.8 |
TKR (%) | 0 | 0 | N/A | 0 | 0 | 0 | 0 |
TRPV1 585 Ile–Ile (%) | 14.4 | 11.9 | N/A | 11.7 | 17.1 | 17.6 | 18.4 |
MAF (%) | 38.2 | 40.4 | N/A | 37.4 | 40.2 | 43.5 | 43.4 |
Unaffected | n=743 | n=542 | n=728 | n=532 | n=978 | n=0 | n=329 |
Age years mean (SD) | 62.6 (8.4) | 64.8 (2.7) | 66.3 (7.4) | 62.9 (5.7) | 52.9 (7.2) | N/A | 61.8 (7.5) |
Female (%) | 49.9 | 50.1 | 57.4 | 100 | 100 | N/A | 47.9 |
BMI (kg/m2) mean (SD) | 27.1 (4.4) | 26.2 (3.8) | 26.6(3.9) | 24.7 (3.6) | 24.5 (4.0) | N/A | 27.4 (4.4) |
TRPV1 585 Ile–Ile (%) | 15.5 | 15.6 | 16.1 | 13.6 | 15.0 | N/A | 16.20 |
MAF (%) | 38.5 | 38.5 | 37.8 | 38.1 | 37.8 | 38.8 |
BMI, body mass index; K/L, Kellgren–Lawrence; MAF, minor allele frequency; TKR, total knee replacement.