Table 1

Association of proposed risk factors with lymphoma occurrence in the pSS study cohort

LymphomaNo lymphomap Value*
GC positivity†6 (86%)37 (22%)0.001
CD4 T lymphocytopaenia†‡4 (80%)15 (14%)0.003
C3, lowest quartile†3 (50%)36 (24%)0.17
C4, lowest quartile†4 (67%)29 (25%)0.043
Cryoglobulinaemia†2 (33%)13 (16%)0.261

  • ↵* Fisher's exact test.

  • ↵† Values represent n/% of available.

  • ↵‡ CD4 T lymphocytopaenia: either CD4 T cells less than 300 cells/ml or CD4 T cells less than 30% of total lymphocyte count or low CD4/CD8 ratio: less than 0.8.

  • GC, germinal centre; pSS, primary Sjögren's syndrome.