Demographic and baseline clinical characteristics of study groups
| HA (n=153) | Placebo (n=153) | |
|---|---|---|
| Women, n (%) | 128 (83.7) | 128 (83.7) |
| Age, years (mean (SD)) | 63 (8.2) | 63.9 (8.9) |
| BMI, kg/m2 (mean (SD)) | 28.4 (2.7) | 28.7 (2.6) |
| Duration knee osteoarthritis, years (mean (SD)) | 6.9 (6.8) | 8.1 (8.4) |
| Osteoarthritis baseline characteristics | ||
| Pain, VAS 0–100 (mean (SD)) | 69.7 (11.1) | 71.2 (11.2) |
| Morning stiffness, <30 min (n (%)) | 142 (92.8) | 133 (86.9) |
| Joint crackles, n (%) | 141 (92.2) | 138 (90.2) |
| Kellgren–Lawrence grade, n (%) | ||
| II | 108 (70.6) | 114 (74.5) |
| III | 45 (29.4) | 39 (25.5) |
| Joint space width, mm (mean (SD)) | 3.5 (0.82) | 3.5 (0.89) |
| WOMAC, VAS 0–100 (mean (SD)) | ||
| Total | 55.7 (15.5) | 58.2 (14.7) |
| Pain | 56.0 (16.7) | 56.7 (15.2) |
| Stiffness | 54.8 (23.0) | 54.8 (22.4) |
| Function | 57.1 (17.0) | 59.1 (15.1) |
BMI, body mass index; HA, hyaluronic acid; VAS, visual analogue scale; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.