Baseline characteristics of patients
| Variable | Total study population (n=232) | Doxycycline (n=116) | Placebo (n=116) |
|---|---|---|---|
| Women, n (%) | 154 (66) | 79 (68) | 75 (65) |
| Age (years), mean (SD) | 59 (9) | 59 (9) | 59 (10) |
| BMI, mean (SD) | 30 (5) | 30 (6) | 30 (5) |
| Duration of knee complaints (years), median (p25–75) | 6 (3–15) | 6 (3–14) | 6 (3–15) |
| K&L score = 2, number (%) | 151 (65) | 76 (66) | 75 (65) |
| K&L score = 3, number (%) | 81 (35) | 40 (34) | 41 (35) |
| WOMAC score, mean (SD) | |||
| Pain | 49 (18) | 52 (19) | 46 (17) |
| Function | 49 (18) | 52 (18) | 47 (17) |
| Stiffness | 56 (21) | 58 (22) | 54 (19) |
| Severe pain, n (%)* | 37 (16) | 19 (16) | 18 (16) |
| VAS–PGA, mean (SD) | 52 (25) | 52 (25) | 53 (26) |
| Pain medication use, number (%)† | |||
| Paracetamol | 81 (35) | 50 (43) | 31 (27) |
| NSAID | 95 (41) | 51 (44) | 44 (38) |
| Tramadol | 12 (5) | 4 (3) | 8 (7) |
| None | 85 (37) | 34 (29) | 51 (44) |