Baseline and 12-month follow-up clinical and biological characteristics of patients with and without erosions at diagnosis
| Characteristics | Baseline characteristics of erosive patients at diagnosis (34 patients) | Baseline characteristics of not erosive patients at diagnosis (87 patients) | Follow-up characteristics of erosive patients at diagnosis (34 patients) | Follow-up characteristics of not erosive patients at diagnosis (87 patients) |
|---|---|---|---|---|
| Age, years | 57.7±10.6 | 2.1±13.9 | – | – |
| Disease duration, months | 7.1±3.0 | 5.2±3.4* | – | – |
| VERA, n (%) | 6 (17.6%) | 28 (32.2%)* | – | – |
| ACPA, U/ml | 60.6±57.1 | 74.1±108.2 | 39.3±38.4 | 46.7±39.1 |
| ACPA+, n (%) | 27 (79.4%) | 61 (70.1%) | 22 (66.7%) | 57 (65.5%) |
| RF-IgM, U/ml | 122.4±158.2 | 79.3±107.6 | 52.9±76.7 | 29.4±51.2 |
| RF-IgM+, n (%) | 25 (73.5%) | 57 (65.5%) | 14 (42.4%) | 24 (27.6%) |
| RF-IgA, U/ml | 186.6±230.9 | 164.0±203.8 | 40.9±67.6 | 49.8±104.8 |
| RF-IgA+, n (%) | 16 (47.1%) | 29 (33.3%) | 5 (15.2%) | 15 (7.4%) |
| ESR, mm/I° h | 41.5±25.0 | 35.5±24.6 | 20.1±19.2 | 14.0±11.1† |
| CRP, mg/litre (T=0) | 27.4±33.7 | 20.1±27.9 | 4.8±9.4 | 4.0±4.8 |
| DAS44 | 3.5±0.9 | 3.2±0.8 | 1.8±0.8 | 1.6±0.9 |
| HAQ-DI (T=0) | 1.3±0.8 | 1.2±0.7 | 0.5±0.6 | 0.3±0.5 |
| DAS remission | – | – | 15 (44.1%) | 41 (47.1%) |
| HAQ remission | – | – | 22 (64.7%) | 69 (79.3%) |
| ACR remission | – | – | 9 (26.5%) | 34 (39.1%) |
Clinical and biological values of variables in patients that were erosive or not erosive at baseline. The values are indicated as the mean±SD.
↵* p<0.05 between baseline characteristics of patients with and without erosion at diagnosis.
↵† p<0.05 between 12-month characteristics of patients with and without erosion at diagnosis.
ACR, American College of Rheumatology; ACPA, anti-cyclic citrullinated peptide antibodies; CRP, C reactive protein; DAS, Disease Activity Score; ESR, erythrocyte sedimentation rate; HAQ-DI, Health Assessment Questionnaire Disability Index; RF, rheumatoid factor; VERA, very early rheumatoid arthritis.