Associations of predictor variables with selected outcome instruments
| ASDAS clinically important improvement 3 months | ASAS20 response 3 months | |||||
|---|---|---|---|---|---|---|
| OR | Lower 95% CI | Upper 95% CI | OR | Lower 95% CI | Upper 95% CI | |
| Anti-TNF vs conventional | 17.7 | 10.0 | 31.3 | 5.8 | 3.7 | 9.0 |
| HLA-27+ vs HLA-27− | 1.3 | 0.7 | 2.2 | 1.7 | 1.1 | 2.9 |
| Age ≤40 vs >40 years | 2.2 | 1.5 | 3.4 | 1.7 | 1.2 | 2.4 |
| CRP high vs low | 9.3 | 5.5 | 16.0 | 2.2 | 1.4 | 3.4 |
| CRP moderate vs low | 3.5 | 2.2 | 5.7 | 1.2 | 0.8 | 1.9 |
| Berlin enthesitis score 0 vs >0 | 0.9 | 0.6 | 1.3 | 1.2 | 0.8 | 1.6 |
| BASFI low vs high | 2.2 | 1.3 | 3.6 | 1.5 | 1.0 | 2.4 |
| BASFI moderate vs high | 2.2 | 1.3 | 3.6 | 1.9 | 1.2 | 3.0 |
| ASDAS major improvement 3 months | BASDAI50 response 3 months | |||||
| OR | Lower 95% CI | Upper 95% CI | OR | Lower 95% CI | Upper 95% CI | |
| Anti-TNF vs conventional | 14.2 | 6.5 | 31.1 | 8.7 | 4.9 | 15.6 |
| HLA-27+ vs HLA-27− | 2.4 | 1.2 | 4.7 | 2.5 | 1.4 | 4.5 |
| Age ≤40 or >40 years | 1.8 | 1.2 | 2.9 | 1.9 | 1.3 | 2.8 |
| CRP high vs low | 15.0 | 7.9 | 28.6 | 3.6 | 2.2 | 5.8 |
| CRP moderate vs low | 4.1 | 2.2 | 7.8 | 2.3 | 1.4 | 3.7 |
| Berlin enthesitis score 0 vs >0 | 1.6 | 1.0 | 2.5 | 1.4 | 1.0 | 2.1 |
| BASFI low vs high | 1.635 | 0.9 | 2.8 | 3.4 | 2.1 | 5.5 |
| BASFI moderate vs high | 1.4 | 0.8 | 2.4 | 3.0 | 1.8 | 4.8 |
| ASDAS inactive disease 6 months | ASAS partial remission 6 months | |||||
| OR | Lower 95% CI | Upper 95% CI | OR | Lower 95% CI | Upper 95% CI | |
| Anti-TNF vs conventional | 46.5 | 6.4 | 339.6 | 16.8 | 5.2 | 54.4 |
| HLA-27+ vs HLA-27− | 2.4 | 1.0 | 5.5 | 2.2 | 1.0 | 5.0 |
| Age ≤40 or >40 years | 1.6 | 1.0 | 2.6 | 1.6 | 1.0 | 2.6 |
| CRP high vs low | 2.3 | 1.3 | 4.2 | 2.1 | 1.2 | 3.7 |
| CRP moderate vs low | 1.6 | 0.9 | 3.0 | 1.3 | 0.8 | 2.4 |
| Berlin enthesitis score 0 vs >0 | 1.5 | 0.9 | 2.4 | 1.3 | 0.8 | 2.1 |
| BASFI low vs high | 3.2 | 1.7 | 5.9 | 4.1 | 2.2 | 7.6 |
| BASFI moderate vs high | 1.8 | 1.0 | 3.5 | 2.6 | 1.4 | 4.8 |
ASDAS, ankylosing spondylitis disease activity score; ASAS, assessment of spondyloarthritis; BASDAI, Bath ankylosing spondylitis disease activity index; BASFI, Bath ankylosing spondylitis functional index; CRP, C-reactive protein; TNF, tumour necrosis factor.