Various definitions developed for remission in rheumatoid arthritis over time
| ARA9 (1981) | DAS12 (1996)* | DAS2813 (2004)† | SDAI16 (2005)‡ | CDAI16 (2005)§ | ACR/EULAR8 (2010) | |
|---|---|---|---|---|---|---|
| Cut-off for remission | 5/6 for 2 consecutive months | <1.6 | <2.4 | ≤3.3 | ≤2.6 | 4/4 at one time point |
| Elements included | ||||||
| Morning stiffness | ≤15 min | – | – | – | – | – |
| Fatigue | None | – | – | – | – | – |
| Joint pain | None | – | – | – | – | – |
| Tender joint count | 0 | Ritchie articular index | 28 joints | 28 joints | 28 joints | 28 joints |
| Swollen joint count | 0 | 44 joints | 28 joints | 28 joints | 28 joints | 28 joints |
| ESR/CRP | ESR<20 (men) | ESR (mm/h) | ESR (mm/h) | CRP (mg/dl) | Not included | CRP (mg/dl) |
| ESR<30 (women) | ||||||
| Patient's GH | – | 0–100 scale | 0–100 scale | 0–10 scale | 0–10 scale | 0–10 scale |
| Physician's GH | – | – | – | 0–10 scale | 0–10 scale | – |
↵* DAS = 0.53938 × √(Ritchie) + 0.06465 × (Swollen joints) + 0.330 × ln (ESR) + 0.00722 × (GH).
↵† DAS28 = 0.56 × √(TJC28) + 0.28 × √(SJC28) + 0.70 × ln (ESR) + 0.014 × (GH).
↵‡ SDAI, the sum of the five elements.
↵§ CDAI, the sum of the four elements.
ACR, American College of Rheumatology; ARA, American Rheumatism Association; CDAI, Clinical Disease Activity Index; CRP, C reactive protein; DAS, Disease Activity Score; ESR, erythrocyte sedimentation rate; EULAR, European League Against. Rheumatism; GH, global assessment; SDAI, Simple Disease Activity Index; SJC28, 28 joint count for swollenness; TJC28, 28 joint count for tenderness.