Patient demographics and disease characteristics at baseline by treatment group
| Treatment group | |||
|---|---|---|---|
| Characteristics | Placebo (n=43) | Etanercept (n=39) | All (n=82) |
| Age, years | 48±10 | 46±11 | 47±10 |
| Men, n (%) | 39 (91%) | 37 (95%) | 76 (93%) |
| Disease duration, years | 23±11 | 19±10 | 21±11 |
| HLA B27 positive, n (%) | 36 (86%) | 31 (79%) | 67 (83%) |
| Past history or present symptoms, n (%) | |||
| Peripheral arthritis | 19 (44%) | 18 (46%) | 37 (45%) |
| Enthesiopathy | 18 (42%) | 11 (28%) | 29 (35%) |
| Uveitis | 12 (28%) | 13 (33%) | 25 (30%) |
| Psoriasis | 5 (12%) | 4 (10%) | 9 (11%) |
| Spinal radiological stage, n (%) | |||
| II | 3 (7%) | 7 (18%) | 10 (12%) |
| III | 26 (60%) | 21 (54%) | 47 (57%) |
| IV | 9 (21%) | 7 (18%) | 16 (20%) |
| V | 5 (12%) | 4 (10%) | 9 (11%) |
| Intervertebral radiological fusion (0–24) | 10±6 | 9±6 | 10±6 |
| Radiological mSASSS (0–72) | 39±19 | 34±22 | 37±21 |
| Radiological hip abnormalities (coxitis)* | 14(35%) | 12 (32%) | 26 (33%) |
| BASDAI (0–100) | 58±15 | 64±12 | 61±13 |
| BASFI (0–100) | 57±19 | 63±20 | 60±19 |
| BASMI (0–10) | 5.8±1.3 | 5.7±1.4 | 57±1.3 |
| Total back pain (0–100) | 61±20 | 70±16 | 65 (±19 |
| CRP level, mg/l | 17±19 | 25±31 | 21±26 |
| ASDAS-CRP | 3.63±0.76 | 3.90±0.71 | 3.76±0.75 |
| Disease activity state, n (%) | |||
| ASDAS-CRP <1.3 (inactive disease) | 0 (0) | 0 (0) | 0 (0) |
| ASDAS-CRP >1.3–<2.1 (moderate disease activity) | 1 (2.4) | 0 (0) | 1 (1.3) |
| ASDAS-CRP >2.1–<3.5 (high disease activity) | 17 (41.5) | 12 (30.8) | 29 (36.3) |
| ASDAS-CRP ≥3.5 (very high disease activity) | 23 (56.1) | 27 (69.2) | 50 (62.5) |
Data are mean±SD.
↵* On pelvic x-ray assessment (eg, BASRI-hip score of at least 2 at either the right or left hip).
ASDAS-CRP, Ankylosing Spondylitis Disease Activity Score-CRP; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; BASFI, Bath Ankylosing Spondylitis Functional Index; BASMI, Bath Ankylosing Spondylitis Metrology Index; CRP, C reactive protein; mSASSS, modified Stoke Ankylosing Spondylitis Spine Score.