Comparisons of CFTR mutation frequencies in the different groups of family members and in unaffected relatives
| Phenotype (number of affected/unaffected) | CFTR mutations | Frequency in affected individualsaccounting for relatedness | Frequency in unaffected individualsaccounting for relatedness | OR | 95% CI | p Value |
|---|---|---|---|---|---|---|
| RA-DB (30/76) | All mutations | 0.329 | 0.163 | 3.42 | 1.50 to 7.79 | 0.003 |
| A | 0.077 | 0.056 | 1.41 | 0.79 to 2.52 | 0.247 | |
| B* | 0.087 | 0.017 | 3.52 | 0.73 to 16.81 | 0.115 | |
| C | 0.164 | 0.091 | 4.92 | 1.86 to 13.02 | 0.001 | |
| DB only (8/76) | All mutations | 0.500 | 0.163 | 4.91 | 2.35 to 10.26 | 2.3×10−5 |
| A | 0.308 | 0.056 | 9.14 | 3.75 to 22.25 | 1.1×10−6 | |
| B | 0.077 | 0.017 | 2.57 | 0.91 to 7.23 | 0.867 | |
| C | 0.115 | 0.091 | 2.83 | 0.56 to 14.41 | 0.210 | |
| RA only (24/76) | All mutations | 0.109 | 0.163 | 1 | 0.42 to 2.36 | 1.000 |
| A* | 0.000 | 0.056 | 0.31 | 0 to 2.17 | 0.191 | |
| B | 0.026 | 0.017 | 0.78 | 0.04 to 13.82 | 0.867 | |
| C | 0.083 | 0.091 | 2.24 | 0.97 to 5.14 | 0.058 |
↵* Use of exact logistic regression.
See text for classification of CFTR mutations.
RA, rheumatoid arthritis; DB, diffuse bronchiectasis; RA-DB, RA-associated DB.