Genotype counts and frequencies for SNP mapping to chromosome 2p in UK RA cases and controls and association of SNP in subgroups stratified by autoantibody status
| rs13031237 | rs13017599 | |
|---|---|---|
| Case, n (%) | ||
| 2/2 | 508 (14.9) | 507 (14.8) |
| 1/2 | 1674 (49.0) | 1672 (48.9) |
| 1/1 | 1234 (36.1) | 1239 (36.2) |
| Control, n (%) | ||
| 2/2 | 350 (12.7) | 352 (12.8) |
| 1/2 | 1271 (46.2) | 1270 (46.1) |
| 1/1 | 1128 (41.1) | 1133 (41.1) |
| Case–control comparison | ||
| p-Trend | 5.26×10−5 | 6.96×10−5 |
| Allelic OR (95% CI) | 1.16 (1.08 to 1.25) | 1.16 (1.08 to 1.25) |
| RF+ (n=2370) vs controls (n=2758) | ||
| p-Trend | 2.83E−06 | 3.91E−06 |
| Allelic OR (95% CI) | 1.21 (1.12 to 1.31) | 1.21 (1.11 to 1.31) |
| RF− (n=784) vs controls (n=2758) | ||
| p-Trend | 0.37 | 0.42 |
| Allelic OR (95% CI) | 1.06 (0.94 to 1.19) | 1.05 (0.93 to 1.18) |
| Anti-CCP+ (n=1184) vs controls (n=2758) | ||
| p-Trend | 2.12E−05 | 2.67E−05 |
| Allelic OR (95% CI) | 1.24 (1.12 to 1.37) | 1.23 (1.12 to 1.36) |
| Anti-CCP− (n=433) vs controls (n=2758) | ||
| p-Trend | 0.34 | 0.41 |
| Allelic OR (95% CI) | 0.93 (0.8 to 1.08) | 0.94 (0.81 to 1.09) |
| Auto-antibody+ (n=2593) vs controls (n=2758) | ||
| p-Trend | 7.71×10−7 | 1.01×10−6 |
| Allelic OR (95% CI) | 1.22 (1.12 to 1.31) | 1.21 (1.12 to 1.31) |
1, major allele; 2, minor allele; Anti-CCP+, anti-cyclic citrullinated peptide antibody positive; Anti-CCP−, anticyclic citrullinated peptide antibody negative; Auto-antibody +, positive for either rheumatoid factor or anticyclic citrullinated peptide antibodies; OR, odds ratio; RA, rheumatoid arthritis; RF+, rheumatoid factor positive; RF−, rheumatoid factor negative; SNP, single nucleotide polymorphism.