HLA-class II allelic frequencies significantly associated with antitopoisomerase I antibody positive Caucasian, African-American and Hispanic patients with systemic sclerosis (SSc) compared with ethnically matched normal controls using logistic regression
| SSc (%) | Controls (%) | Model (D/R/A) | p Value | OR | 95% CI | |
|---|---|---|---|---|---|---|
| Caucasian† | ||||||
| DRB1 | ||||||
| *0401 | 3.6 | 8.3 | D | 0.003 | 0.35 | 0.2 to 0.7 |
| 1101 | 6.2 | 3.8 | D | 0.03 | 2.13 | 1.1 to 4.1 |
| *1104 | 16.6 | 3.0 | D | <0.0001 | 6.93 | 3.9 to 12.2 |
| DQA1 | ||||||
| *0501 | 34.7 | 24.0 | A | <0.0001 | 2.01 | 0.9 to 4.7 |
| 2.80 | 1.8 to 4.2 | |||||
| DQB1 | ||||||
| *0202 | 5.2 | 10.3 | D | 0.006 | 0.44 | 0.2 to 0.8 |
| *03 | 45.1 | 30.1 | A | 0.0004 | 3.30 | 1.8 to 6.2 |
| 1.76 | 1.1 to 2.7 | |||||
| *0301 | 31.2 | 16.8 | D | <0.0001 | 3.20 | 2.1 to 4.8 |
| *DQB1 26 epi | 72.2 | 53.8 | – | <0.0001 | 2.47 | 1.6 to 3.8 |
| DPB1 | ||||||
| *1301 | 12.2 | 1.4 | D | <0.0001 | 14.02 | 6.5 to 30.3 |
| African-American‡ | ||||||
| DRB1 | ||||||
| *08 | 12.5 | 5.5 | D | 0.04 | 2.64 | 1.1 to 6.1 |
| *0804 | 11.3 | 3.6 | D | 0.01 | 3.42 | 1.3 to 9.0 |
| *11 | 28.8 | 13.4 | D | 0.0005 | 3.55 | 1.8 to 7.2 |
| *1101 | 12.5 | 5.7 | D | 0.13 | 1.98 | 0.8 to 4.9 |
| *1104 | 8.8 | 1.9 | D | 0.007 | 4.66 | 1.6 to 13.4 |
| DQB1 | ||||||
| *0301 | 40.0 | 14.9 | D | 0.0002 | 3.90 | 1.9 to 8.1 |
| *DQB1 26 epi | 87.5 | 63.0 | – | 0.003 | 3.91 | 1.5 to 10.4 |
| Hispanic§ | ||||||
| DRB1 | ||||||
| *08 | 23.6 | 9.9 | D | 0.08 | 2.00 | 0.9 to 4.4 |
| *0802 | 20.8 | 8.3 | D | 0.13 | 1.91 | 0.8 to 4.3 |
| *1104 | 22.2 | 2.0 | D | <0.0001 | 15.96 | 5.3 to 48.0 |
| DQA1 | ||||||
| *0401 | 26.4 | 9.1 | D | 0.008 | 3.05 | 1.4 to 6.7 |
| *0301 | 24.3 | 14.9 | D | 0.01 | 2.88 | 1.3 to 6.3 |
| DQB1 | ||||||
| *0402 | 25.7 | 8.1 | D | 0.003 | 3.46 | 1.6 to 7.7 |
| *DQB1 26 epi | 78.4 | 61.7 | – | 0.03 | 2.59 | 1.1 to 6.1 |