HLA-class II allelic frequencies significantly associated with Caucasian patients with systemic sclerosis (SSc) compared with Caucasian normal controls using logistic regression
| SSc (%) | Controls (%) | Model (D/R/A) | p Value | OR | 95% CI | |
|---|---|---|---|---|---|---|
| *0404 | 4.3 | 1.9 | D | 0.003 | 2.33 | 1.3 to 4.1 |
| *0701 | 8.0 | 14.2 | A | <0.0001 | 0.39 | 0.1 to 1.1 |
| 0.43 | 0.3 to 0.6 | |||||
| *11 | 13.5 | 8.2 | D | 0.0002 | 1.81 | 1.3 to 2.4 |
| *1104 | 7.1 | 3.0 | D | <0.0001 | 2.48 | 1.6 to 3.9 |
| *1501 | 11.0 | 14.3 | R | 0.0003 | 0.22 | 0.1 to 0.5 |
| DQA1† | ||||||
| *0102 | 18.1 | 21.3 | R | 0.0002 | 0.36 | 0.2 to 0.6 |
| *0201 | 7.6 | 14.4 | A | <0.0001 | 0.20 | 0.1 to 0.6 |
| 0.43 | 0.3 to 0.6 | |||||
| *0501 | 31.6 | 24.0 | A | <0.0001 | 2.29 | 1.4 to 3.7 |
| 1.66 | 1.3 to 2.2 | |||||
| DQB1† | ||||||
| *0202 | 5.4 | 10.3 | D | <0.0001 | 0.46 | 0.3 to 0.7 |
| *0301 | 23.0 | 16.8 | D | 0.002 | 1.50 | 1.2 to 1.9 |
| *0602 | 11.5 | 14.6 | R | 0.003 | 0.29 | 0.1 to 0.7 |
| *DQB1 26 epi | 64.4 | 53.8 | – | 0.0003 | 1.59 | 1.2 to 2.0 |
| DPB1‡ | ||||||
| *1301 | 3.7 | 1.4 | D | 0.004 | 3.18 | 1.4 to 7.3 |