GWAS meta-analysis11 | US validation11 | UK validation | Meta-analysis | |||||||
---|---|---|---|---|---|---|---|---|---|---|
Locus | SNP | p Value | OR | p Value | OR | p Value | OR (95% CI) | p Value | OR (95% CI) | Breslow–Day p value |
CD40 | rs4810485 | 2.4×10−7 | 0.83 | 0.003 | 0.91 | 2×10−4 | 0.86 (0.79 to 0.93) | 7.8×10−8 | 0.87 (0.83 to 0.92) | 0.31 |
CCL21 | rs2812378 | 6.9×10−5 | 1.13 | 9.7×10−4 | 1.10 | 0.04 | 1.08 (1.01 to 1.16) | 1.2×10−4 | 1.09 (1.04 to 1.14) | 0.81 |
CDK6 | rs42041 | 5.5×10−5 | 1.15 | 0.01 | 1.08 | 0.91 | 0.99 (0.92 to 1.08) | 0.002 | 1.08 (1.03 to 1.14) | 0.02 |
GWAS, genome-wide association studies; SNP, single nucleotide polymorphism. |