Bivariate variance component analysis of LDD summary score with lumbar spine BMD with simultaneous adjustment for covariates
| Parameter | Lumbar spine BMD | LDD summary score | Hip BMD |
|---|---|---|---|
| σAD2 | 0.660±0.038 | 0.483±0.045 | 0.571±0.030 |
| σRS2 | 0.131±0.014 | 0.225±0.025 | 0.165±0.007 |
| α0 | 0.255±0.046 | −0.0062±0.035 | 0.017±0.015 |
| βEXCERCISE | NS | NS | NS |
| βWEIGHT | 0.372±0.034 | 0.127±0.030 | 0.405±0.012 |
| βAGE | −0.521±0.061 | 0.516±0.035 | −0.346±0.016 |
| Pairwise correlations with LDD summary score: | |||
| RPHENOTYPE | 0.247±0.031 | 0.182±0.033 | |
| RADD GENETIC | 0.232±0.050 | 0.137±0.049 | |
| RENVIRONMETAL | 0.205±0.074 | NS | |
All variables were standardised prior to genetic analysis.
σAD2/σRS2, variance component estimates attributable to genetic and random environmental effects for each variable separately. σAD2 is equal to heritability estimate, h2.
α0 and β are regression parameters, intercept and slop, reflecting influence of the potential risk factors.
Pairwise correlations are between lumbar spine BMD and LDD, and between hip BMD and LDD, respectively.
BMD, bone mineral density; LDD, lumbar degenerative disc disease.