PADI4_94 (rs2240340) genotypes in current and WTCCC cohorts
| RA cases* | Controls* | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11 | 12 | 22 | MAF | 11 | 12 | 22 | MAF | Allele 2 vs allele 1 OR (95% CI) | p Trend | 12 vs 11 OR (95% CI) | 22 vs 11 OR (95% CI) | |
| Current cohort | 1238 (33.2) | 1841 (49.3) | 653 (17.5) | 0.42 | 1018 (33.5) | 1508 (49.6) | 513 (16.9) | 0.42 | 1.02 (0.95 to 1.09) | 0.58 | 1.00 (0.90 to 1.12) | 1.05 (0.91 to 1.20) |
| WTCCC | 665 (35.8) | 860 (48.3) | 334 (18.0) | 0.41 | 1031 (35.1) | 1434 (48.9) | 470 (16.0) | 0.40 | 1.03 (0.95 to 1.12) | 0.54 | 0.93 (0.82 to 1.06) | 1.10 (0.93 to 1.30) |
| WTCCC plus non-autoimmune controls | 665 (35.8) | 860 (48.3) | 334 (18.0) | 0.41 | 3614 (34.1) | 5154 (48.6) | 1831 (17.3) | 0.42 | 0.98 (0.91 to 1.05) | 0.59 | 0.91 (0.81 to 1.01) | 0.99 (0.86 to 1.14) |
| Combined analysis | 1903 (34.0) | 2701 (48.3) | 987 (17.7) | 0.42 | 4632 (34.0) | 6662 (48.8) | 2344 (17.2) | 0.42 | 1.01 (0.96 to 1.05) | 0.72 | 0.99 (0.92 to 1.06) | 1.02 (0.94 to 1.12) |
↵* Data shown as number (%).
1, major (common) allele; 2, minor (rare) allele; MAF, minor allele frequency; WTCCC, Wellcome Trust Case Control Consortium.