Table 3

Haplotype analysis of the 5-SNP marker set in the tumour necrosis factor ligand superfamily member 4 gene (TNFSF4) in Caucasian patients with SSc and controls

Haplotype^*	Controls (N=694)	SSc (N=1050)	χ²	p_U	Effect direction
OMNIBUS	NA	NA	164.3	<0.0001
C-G-A-A-C	0.6%	4.9%	52.6	<0.0001	Risk
C-G-A-G-C	43.4%	35.1%	25.3	<0.0001	Protective
G-G-C-G-C	0.4%	1.7%	12.1	0.0006	Risk
G-G-C-G-T	0.0%	1.4%	20.6	<0.0001	Risk
G-T-C-G-C	0.6%	3.9%	37.6	<0.0001	Risk
Others^†	55.0%	53.0%			Neutral

↵* The order of the SNPs is rs1234314–rs2205960–rs844644–rs844648–rs844665.
↵† Includes 23 other haplotypes.
NA, not applicable; p_U, uncorrected χ² p values; SSc, systemic sclerosis; SNP, single nucleotide polymorphism.