Primary efficacy endpoint—WOMAC A (pain) change over 26 weeks (ITT population)
| Baseline mean (SE) | 26-Week mean (SE) | Estimated change (SE) | Estimated difference between groups (SE) | p Value | |
| Hylan G-F 20 (n = 124) | 2.30 (0.038) | 1.43 (0.060) | −0.84 (0.060) | −0.15 (0.076) | 0.047 |
| Placebo (n = 129) | 2.25 (0.036) | 1.59 (0.058) | −0.69 (0.058) |
ITT, intent-to-treat; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.