| Outcome | Hazard ratio among DE033 patients (95% CI) |
| Achieve ACR20 | 1.890 (1.477 to 2.419) |
| Achieve ACR50 | 1.949 (1.353 to 2.806) |
| Achieve ACR70 | 2.088 (1.137 to 3.836) |
| Achieve EULAR good response | 1.625 (1.188 to 2.224) |
| Achieve disease remission—all patients | 1.826 (1.323 to 2.520) |
| Achieve disease remission—patients without remission at study enrolment | 2.511 (1.721 to 3.662) |
*From proportional hazards regressions controlling for time to event (ACR response or disease remission), duration of study enrolment, percentage working at baseline (for analysis of all patients only) and baseline age, erythrocyte sedimentation rate, C-reactive protein concentration, number of swollen and tender joints, DAS28, and joint pain, patient-rated global and physician-rated global assessment visual analogue scale scores.