| Baseline | Week 48 | Change | 95% CI | |
| Domain scores (norm-based) | ||||
| Physical functioning* | 28.76 (1.24) | 27.72 (1.48) | –1.04 (1.37) | –3.79 to 1.71 |
| Role, physical* | 27.47 (2.15) | 26.19 (1.89) | –1.28 (2.25) | –5.81 to 3.25 |
| Pain | 43.00 (1.55) | 41.92 (1.74) | –1.08 (1.60) | –4.29 to 2.14 |
| General health perception* | 33.89 (1.24) | 32.42 (1.24) | –1.47 (1.35) | –4.19 to 1.25 |
| Vitality* | 40.63 (1.41) | 40.15 (1.47) | –0.49 (1.32) | –3.15 to 2.17 |
| Social functioning | 39.67 (1.81) | 38.51 (2.13) | –1.16 (2.26) | –5.70 to 3.38 |
| Role, emotional† | 32.73 (3.03) | 30.65 (3.10) | –2.07 (3.65) | –9.43 to 5.29 |
| Mental health* | 45.11 (1.65) | 42.94 (1.98) | –2.17 (1.63) | –5.45 to 1.11 |
| Health transition item | 3.81 (0.15) | 2.98 (0.18) | –0.83 (0.22) | –1.27 to –0.39 |
| Health transition item (n) | ||||
| 1: Much better | 3 | 4 | ||
| 2: Somewhat better | 2 | 17 | ||
| 3: About the same | 6 | 9 | ||
| 4: Somewhat worse | 26 | 10 | ||
| 5: Much worse | 10 | 7 |
Values are mean (SEM). Four patients were discontinued because of pulmonary arterial hypertension (PAH) worsening/death and were assigned the worst value observed over the analysis set at week 48, as per protocol. The health transition item is reporting comparison to 1 year before. A decrease (negative change) in a domain score corresponds to deterioration.
n = 47, *n = 46, †n = 45.