No DMARDs | 0.52 (0.45 to 0.60), <0.0001 | 0.61 (0.53 to 0.70), <0.0001 | 0.74 (0.62 to 0.87), 0.0004 | 0.45 (0.38 to 0.53), <0.0001 | 0.53 (0.46 to 0.62), <0.0001 | 0.59 (0.49 to 0.71), <0.0001 |
LEF | 0.69 (0.58 to 0.82), <0.0001 | 0.72 (0.61 to 0.86), 0.0002 | 0.67 (0.54 to 0.84), 0.0006 | 0.68 (0.54 to 0.84), 0.0004 | 0.77 (0.64 to 0.93), 0.0058 | 0.75 (0.6 to 0.93), 0.0103 |
SSZ | 0.61 (0.41 to 0.89), 0.0112 | 0.76 (0.52 to 1.11), 0.1555 | 0.76 (0.46 to 1.26), 0.2817 | 0.72 (0.44 to 1.16), 0.1756 | 0.95 (0.63 to 1.43), 0.8142 | 1.51 (0.97 to 2.36), 0.0694 |
AM | 0.86 (0.58 to 1.26), 0.4292 | 1.14 (0.81 to 1.63), 0.4503 | 1.11 (0.73 to 1.68), 0.6397 | 0.81 (0.51 to 1.30), 0.3859 | 0.99 (0.67 to 1.44), 0.9420 | 1.03 (0.65 to 1.62), 0.9107 |
1 other DMARD* | 0.82 (0.49 to 1.37), 0.4515 | 0.92 (0.57 to 1.48), 0.7280 | 1.08 (0.61 to 1.94), 0.7871 | 0.79 (0.42 to 1.46), 0.4446 | 0.97 (0.57 to 1.65), 0.9157 | 0.93 (0.48 to 1.81), 0.8365 |
MTX+LEF | 0.67 (0.48 to 0.95), 0.0233 | 0.70 (0.50 to 0.97), 0.0307 | 0.72 (0.47 to 1.11), 0.1387 | 0.92 (0.59 to 1.45), 0.7183 | 0.72 (0.50 to 1.02), 0.0673 | 0.82 (0.53 to 1.25), 0.3491 |
MTX+AM | 1.01 (0.74 to 1.38), 0.9465 | 0.94 (0.72 to 1.23), 0.6590 | 0.89 (0.64 to 1.24), 0.4860 | 1.33 (0.87 to 2.03), 0.1922 | 0.99 (0.75 to 1.32), 0.9493 | 0.97 (0.69 to 1.34), 0.8310 |
MTX+SSZ | 1.01 (0.71 to 1.45), 0.9452 | 1.0 (0.73 to 1.36), 0.9822 | 0.99 (0.67 to 1.44), 0.9438 | 1.36 (0.82 to 2.24), 0.2366 | 0.94 (0.67 to 1.32), 0.7336 | 1.01 (0.68 to 1.48), 0.9729 |
MTX+SSZ+AM | 0.86 (0.51 to 1.45), 0.5708 | 0.97 (0.59 to 1.57), 0.8849 | 1.11 (0.62 to 2.0), 0.7208 | 2.89 (1.04 to 8.01), 0.0411 | 1.24 (0.74 to 2.09), 0.4180 | 1.61 (0.91 to 2.84), 0.1006 |