Pharmacological intervention in dendritic cell (DC) biology
| Agent | Biological effect | Ref |
|---|---|---|
| Corticosteroids | Suppresses number of plasmacytoid DC precursors | 52 |
| Restrains monocyte differentiation into DCs | ||
| Suppresses monocyte derived DC maturation | ||
| Suppresses interleukin (IL)-12 production | ||
| Enhances IL-10 production by DCs | ||
| 1,25(OH)2vitamin D3 | Restrains monocyte differentiation into DCs | 9 |
| Suppresses monocyte derived DC maturation | ||
| Suppresses IL-12 production | ||
| Enhances IL-10 production by DCs | ||
| Modulates DC responses to chemotactic signals | ||
| Hydrochloroquine | Prevents lysosomal vacuole acidification | 58 |
| Ciclosporin | Suppresses tumour necrosis factor production | 8 |
| Mycophenolate | Retards DC maturation. Reduces IL-12 production | 59 |
| Tick saliva | Retards Langerhans’ cell migration | 60 |