Renal and global SLE activity before and after 3 months of IAS
| At start of IAS (n = 16) | 3 Months IAS (n = 16) | p Value | |
|---|---|---|---|
| Normal ranges: albumin 34–48 g/l; C3c 0.9–1.8 g/l; C4 0.1–0.4 g/l; creatinine 0–110 μmol/l; creatinine clearance 80–120 ml/min; proteinuria 0–0.18 g/day. | |||
| Results are shown as mean (SD) unless stated otherwise. | |||
| Renal function | |||
| Proteinuria (g/day) | 6.4 (4.0) | 4.5 (4.6) | 0.03 |
| R20/R50 (%) | 69/56 | ||
| Serum albumin (g/l) | 28.5 (8.0) | 29.5 (7.0) | NS |
| Creatinine clearance (ml/min) | 54 (32) | 78 (48) | 0.02 |
| Serum creatinine (μmol/l) | 155 (95) | 140 (105) | NS |
| SLE activity | |||
| SIS | 17 (6) | 6 (3) | <0.0001 |
| R20/R50 (%) | 94/81 | ||
| SLEDAI | 21 (6) | 6 (4) | <0.0001 |
| ECLAM | 8 (3) | 3 (2) | <0.0001 |
| Anti-dsDNA (IU/ml) | 460 (760) | 107 (190) | <0.002 |
| R20/R50 (%) | 81/75 | ||
| C3c (g/l) | 0.4 (0.2) | 0.7 (0.3) | <0.01 |
| C4 (g/l) | 0.1 (0.05) | 0.2 (0.09) | <0.01 |