Up regulated genes expressed in PBMC from patients with SSc without HSCT as indicated by a cDNA array
| Classification | Up regulated genes | GenBank accession No | Ratio (fold increase) | |
|---|---|---|---|---|
| The ratio of the gene expression index (see “Patients and methods”) of patients with SSc without HSCT (n = 6) to healthy controls (n = 5) was calculated, and the list of up regulated genes using cDNA array (with an SSc/control ratio >3.0) is displayed. *Gene expression was confirmed by real time PCR. | ||||
| CaMKIIβ, calcium/calmodulin dependent protein kinase II β; MIP-1β, macrophage inflammatory protein β; MCP-3, monocyte chemoattractant protein-3; RGS-1, regulators of G-protein signalling-1. | ||||
| Regulatory transcription factors | Per1 | AB002107 | 7.61 | |
| Erg-3 | S40832 | 4.50 | ||
| Gfi-1 | U67369 | 4.44 | ||
| Protein kinases | CaMKIIβ | AF078803 | 4.90 | |
| Growth factors and hormones | IL1β* | X02532 | 9.70 | |
| MIP-1β* | J04130 | 6.58 | ||
| TARC | D43767 | 5.56 | ||
| IL12p35 | AF180562 | 4.27 | ||
| MIP-3α* | U77035 | 4.25 | ||
| MCP-3* | X72308 | 3.88 | ||
| Membrane receptors | IL15Rα | U31628 | 3.46 | |
| Signalling intermediates | Gab1 | U43885 | 6.09 | |
| RGS-1* | X73427 | 5.21 | ||
| Shb | X75342 | 4.32 | ||
| TACE* | U86755 | 3.70 | ||
| Dbl | J03639 | 3.38 | ||
| Lymphocyte signalling | CD34 | M81104 | 3.40 | |