Immunohistological measures of inflammation in OA synovial tissue
| Measure | Early | Late | p Value |
|---|---|---|---|
| Results are expressed as mean (SD). Lining layer values represent the cell depth. Factor VIII represents the number of blood vessels/HPF. VEGF is expressed as the sum of three semiquantitative scores (0–4) derived from the lining and sublining layers, and blood vessels. CD4+, CD68+, ICAM-1+, IL1β+, TNFα+, COX-1 and 2+, NF-κB1+, and RelA+ cells are expressed as number of cells/mm2. | |||
| Lining layer | 4.0 (1.9) | 2.3 (1.0) | 0.011 |
| CD4+ | 181.2 (86.2) | 105.8 (43.0) | 0.017 |
| CD68+ | 280.6 (59.9) | 171.9 (58.1) | <0.001 |
| Factor VIII | 9.8 (1.8) | 7.6 ( 2.3) | 0.010 |
| VEGF | 8.3 (2.2) | 4.8 ( 2.7) | 0.001 |
| ICAM-1 | 438.1 (116.7) | 159.9 (56.7) | <0.001 |
| TNFα | 431.2 (101.6) | 210.4 ( 64.5) | <0.001 |
| IL1β | 542.0 (102.1) | 202.5 ( 36.0) | <0.001 |
| COX-1 | 216.3 (102.6) | 218.1 (79.4) | 0.48 |
| COX-2 | 312.8 (114.6) | 233.8 ( 50.7) | 0.04 |
| NF-κB1 | 252.2 (49.1) | 163.4 (47.7) | <0.001 |
| RelA | 134.2 (48.4) | 87.9 (19.8) | 0.015 |