Prevalence of CARD15 variants in the populations according to subtypes defined at baseline
| n | Carriers of CARD15 variant(s) | |
|---|---|---|
| *χ2: p<0.001 (carrier frequency in Crohn’s disease v control population). | ||
| †χ2: p = 0.5 (carrier frequency in general spondyloarthropathies v control population). | ||
| ‡χ2: p = 0.001 (chronic inflammation in patients with CARD15 variant v chronic inflammation in patients without CARD15 polymorphism). | ||
| Classification | ||
| Controls | 140 | 24 (17%) |
| Crohn’s disease | 156 | 77 (49%)* |
| Spondyloarthropathy | 104 | 21 (20%)† |
| Ankylosing spondylitis | 75 | 16 (21%) |
| Undifferentiated spondyloarthropathies | 29 | 5 (17%) |
| Gut histology in the spondyloarthropathy population | ||
| Chronic inflammation | 40 (38%) | 15 (38%)‡ |
| Acute inflammation | 24 (23%) | 0 (0%) |
| Normal histology | 40 (38%) | 6 (15%) |