Table 3

 Genotyping of the ADAMTS3 SNPs intron 1 (−7), exon 3 (+316), and intron 12 (−19) in an additional cohort of 244 female-THR cases

ADAMTS3 SNPAllele frequency (allele numbers) and p value
Female controlsFemale probandsp ValueAdditional female casesp ValueProbands and cases combinedp Value
Intron 1 (−7)0.45 (331/397)0.39 (108/172)0.0590.50 (228/232)0.190.45 (336/404)0.98
Exon 3 (+316)0.38 (284/458)0.33 (97/195)0.160.43 (201/269)0.140.39 (298/464)0.78
Intron 12 (−19)0.03 (22/712)0.07 (19/269)0.0150.05 (23/443)0.120.06 (42/712)0.022