Values for relevant serum markers in patients with primary Sjögren’s syndrome according to the presence of anti-SSA or anti-SSB antibodies
| No antibody | Anti-SSA only | Anti-SSA and anti-SSB | p Value | |
|---|---|---|---|---|
| Values are mean (SD) unless specified. | ||||
| A minimum sequential critical value of p = 0.017 was considered statistically significant according to the number of tests done. | ||||
| BLyS, B lymphocyte stimulator; ESR, erythrocyte sedimentation rate; RF, rheumatoid factor; SSA/SSB, Sjögren’s syndrome antigen A/B. | ||||
| BLyS (ng/ml) | 4.2 (6.8) | 6.6 (8.8) | 5.9 (6.0) | 0.05 |
| β2 Microglobulin (mg/l) | 1.5 (0.6) | 1.82 (0.90) | 2.43 (0.90) | <10−4 |
| Gamma globulin (g/l) | 10.3 (0.9) | 13.9 (4.5) | 16.7 (7.4) | <10−4 |
| IgG (g/l) | 10.8 (4.5) | 15.1 (5.4) | 19.7 (7.1) | <10−4 |
| IgA (g/l) | 2.5 (1.2) | 3.2 (1.8) | 3.4 (1.3) | 0.008 |
| IgM (g/l) | 1.5 (1.3) | 1.3 (0.7) | 1.7 (1.1) | 0.24 |
| RF (IU/ml) | 52.6 (216.5) | 156.8 (257.6) | 234.8 (423.1) | 0.01 |
| Decreased C3 concentration | 11.5% | 6.3% | 11.5% | 0.74 |
| Decreased C4 concentration | 5.8% | 25.6% | 35.2% | 0.001 |
| ESR (mm/h) | 18.8 (18.8) | 29 (26) | 39 (29) | <10−4 |
| C reactive protein (mg/l) | 7.6 (8.4) | 6.2 (2.9) | 8.8 (7.6) | 0.41 |