Frequency of symptomatic osteoarthritis at the various joint sites in the probands and siblings with familial osteoarthritis at multiple sites of the 191 sibling pairs included in the GARP study
| Joints involved | Probands (%) | Siblings (%) |
|---|---|---|
| *p<0.05, probands v siblings. | ||
| CMC1, first carpometacarpal joint; DIP, distal interphalangeal joint; PIP, proximal interphalangeal joint. | ||
| Affected sites with symptomatic osteoarthritis | ||
| Hand | 148 (77) | 128 (67)* |
| DIP, PIP, or CMC1 | 127 (66) | 113 (59) |
| DIP | 93 (49) | 74 (39)* |
| PIP | 81 (42) | 66 (35) |
| CMC1 | 57 (30) | 47 (25) |
| Spine | 145 (76) | 159 (83) |
| Hip | 49 (26) | 44 (23) |
| Knee | 70 (37) | 60 (31) |
| Combination of sites with symptomatic osteoarthritis (%) | ||
| Hand–spine | 112 (59) | 105 (55) |
| Hand–knee | 48 (25) | 34 (18) |
| Hand–hip | 28 (15) | 23 (12) |
| Knee–spine | 51 (27) | 53 (28) |
| Hip–spine | 39 (20) | 39 (20) |
| Hip–knee | 16 (8) | 13 (7) |