Table 1

Characteristics of patients with suspected leflunomide associated peripheral neuropathy

Characteristic	1	2	3	4	5	6	7	8	9	10	11	12	13	14
M, male, F, female; MSAN, motor and sensory axonal neuropathy; SAN, sensory axonal neuropathy; *washout, 10 days cholestyramine after stopping leflunomide; Un, unknown; major concomitant drug: 1, corticosteroids; 2, non-steroidal anti-inflammatory drugs; 3, analgesics; 4, antiulcer drugs; 5, antihypertensive drugs; 6, antidiabetic drugs; 7, anticoagulant drugs; 8, vitamin D substances.
Age at onset	64	66	72	77	80	70	61	78	59	69	64	75	75	59
Sex	M	F	F	M	M	M	F	F	F	M	M	M	F	F
Duration of disease (years)	5	17	1	6	1	10	15	3	5	20	11	3.3	9	43
Duration of treatment at onset of neuropathy (months)	10	19.1	1.7	19	3.2	1	12	0.6	29	2	5	2	24	17
Neurological status before leflunomide	Normal	Normal	Normal	Normal	Dysaesthesia	Normal	Normal	Hypoaesthesia	Normal	Normal	Normal	Dysaesthesia	Normal	Normal
Diabetes mellitus	No	No	Yes	Yes	Yes	No	Yes	No	No	No	No	No	No	No
No previous or concomitant neurotoxic drug	–	–	–	–	–	Almitrine	–	–	–	Atorvastatine	–	Thalidomide	–	–
CNS	SAN	MSAN	SAN	MSAN	MSAN	SAN	SAN	MSAN	SAN	SAN	SAN	SAN	SAN	SAN
pANCA	Yes	No	No	No	Yes	No	No	No	Un	Un	No	Yes	No	No
Concomitant drugs	1, 3, 4, 8	1, 2, 3, 5, 8	5, 6	1, 3, 4, 7	1, 4, 5	1, 2, 4, 5	1, 2, 3, 8, 9	1, 2	1, 2, 4, 5	1, 4	1, 2, 4, 6	1, 3, 4, 5, 8	2, 3, 4	2, 3, 4
Washout*	Yes	No	No	No	No	Yes	Yes	Yes	No	No	No	Yes	Yes	Yes
Outcome after stopping drug	Stabilisation	Recovery	Improvement	Stabilisation	Stabilisation	Improvement	Improvement	Stabilisation	Improvement	Stabilisation	Stabilisation	Improvement	Continuing	Improvement