1. Malar rash |
2. Discoid rash |
3. Photosensitivity |
4. Oral ulcers |
5. Arthritis |
6. Serositis |
(a) Pleuritis |
(b) Pericarditis |
7. Renal disorder |
(a) Proteinuria >0.5 g/24 h or 3+, persistently |
(b) Cellular casts |
8. Neurological disorder |
(a) Seizures |
(b) Psychosis (having excluded other causes—for example, drugs) |
9. Haemolytic disorder |
(a) Haemolytic anaemia |
(b) Leucopenia or <4.0×109/l on two or more occasions |
(c) Lymphopenia or <1.5×109/l on two or more occasions |
(d) Thrombocytopenia <100×109/l |
10. Immunological disorders |
(a) Raised anti-native DNA antibody binding |
(b) Anti-Sm antibody |
(c) Positive finding of antiphospholipid antibodies based on: |
(i) IgG/M anticardiolipin antibodies |
(ii) Lupus anticoagulant |
(iii) False positive serological test for syphilis, present for at least 6 months |
11. Antinuclear antibody in raised titre |