Reasons for permanent discontinuation of methotrexate treatment in 46 of 248 patients with rheumatoid arthritis
| Reason for discontinuation | Discontinued methotrexate permanently (n) | Per cent of discontinuations (n = 46) | Per cent of all patients (n = 248) |
|---|---|---|---|
| Adverse effects | 26 | 56.5% | 10.4% |
| Gastrointestinal | 6 | 13.0% | 2.4% |
| Oral ulcers | 3 | 6.5% | 1.2% |
| Skin rash | 3 | 6.5% | 1.2% |
| Malaise | 3 | 6.5% | 1.2% |
| Pulmonary symptoms | 3 | 6.5% | 1.2% |
| Pneumonia | 2 | 4.3% | 0.8% |
| Nodules | 2 | 4.3% | 0.8% |
| Laboratory abnormalities | 2 | 4.3% | 0.8% |
| Other side effects | 2 | 4.3% | 0.8% |
| Inefficacy | 15 | 32.6% | 6.0% |
| Other reasons | 5 | 10.9% | 2.0% |
| Disease improved | 3 | 6.5% | 1.2% |
| Other diseases | 1 | 2.2% | 0.4% |
| Pregnancy | 1 | 2.2% | 0.4% |