Clinical and laboratory data† of patients with SSc having raised or normal sFKN levels
| Raised sFKN (n = 25) | Normal sFKN (n = 42) | |
|---|---|---|
| *p<0.01 v patients with SSc with normal sFKN levels. | ||
| †Values are percentages unless otherwise stated. | ||
| ESR, erythrocyte sedimentation rate; CRP, C reactive protein. | ||
| Age at onset (years), mean (SD) | 38 (17) | 46 (15) |
| Sex (male:female) | 4:21 | 5:37 |
| Duration (years), mean (SD) | 5.1 (10.5) | 7.7 (7.1) |
| Clinical features | ||
| Pitting scars or skin ulcers | 80* | 38 |
| Short sublingual frenulum | 48 | 59 |
| Contracture of phalanges | 57 | 41 |
| Diffuse pigmentation | 52 | 50 |
| Organ involvement | ||
| Lung | ||
| Pulmonary fibrosis | 64* | 24 |
| Pulmonary hypertension | 21 | 18 |
| Decreased %VC | 64* | 24 |
| Decreased %Tlco | 84* | 40 |
| Oesophagus | 67 | 77 |
| Heart | 19 | 11 |
| Kidney | 0 | 2 |
| Joint | 24 | 24 |
| Muscle | 24 | 17 |
| Laboratory findings | ||
| Antitopoisomerase I antibody | 48 | 29 |
| Anticentromere antibody | 32 | 43 |
| Anti-U1RNP antibody | 8 | 7 |
| Rheumatoid factor | 29 | 13 |
| Raised ESR | 62* | 26 |
| Raised CRP | 33 | 20 |
| Increased IgG | 68 | 45 |