Synovial tissue inflammation† | Synovial fluid† (exudates) | Cartilage involvement‡ | Bone involvement‡ | |
---|---|---|---|---|
Values are median (interquartile range). | ||||
*p<0.02 (CNI-1493 treated v placebo treated group); †by histological grading: 0 = normal, 6 = maximal inflammation; ‡by histological grading: 0 = normal, 6 = maximal destruction. | ||||
Placebo day 23 | 3 (1–3) | 2 (1–2) | 1 (0–2) | 2 (0–2) |
Placebo day 26 | 6 (1–6) | 3 (0–4) | 6 (0–6) | 3 (0–6) |
CNI-1493 day 23 | 0 (0–0) | 0 (0–1) | 0 (0–0) | 0 (0–0) |
CNI-1493 day 26 | 0 (0–3)* | 0 (0–2) | 0 (0–2)* | 0 (0–2) |