Patients’ outcome under anti-TNF alpha therapy
| No. | Sex | Main clinical expression | ASD duration (years) | Age | Main symptoms | Therapy | Remaining symptoms | Follow up | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Type | Associated drug | Response | ||||||||
| PDN, prednisone; AZA, azathioprine; MethylPDN, methylprednisolone; IV Ig, intravenous polyvalent immunoglobulin; MTX, methotrexate. | ||||||||||
| 1 | F | Systemic | 2 | 33 | Fever, arthralgia, rash | Etanercept 25 mg ×2/week | PDN 80 mg/day | Remission | None | 5 months. Anti-TNF stopped (other: drug availability) |
| 2 | F | Articular | 5 | 55 | Fever, polyarthritis, rash | Etanercept 25 mg ×2/week | AZA 100 mg/day PDN 30 mg/day | Partial response | Isolated fever | 12 months. Anti-TNF stopped (lack of efficacy) |
| Infliximab 5 mg/kg | AZA 100 mg/day MethylPDN 1g PDN 30 mg/day | Partial response | Isolated fever | 10 months. Anti-TNF stopped (lack of efficacy) | ||||||
| 3 | M | Articular | 7 | 55 | Polyarthritis | Etanercept 25 mg ×2/week | IV Ig1 | Failure | Polyarthritis | 3 months. Anti-TNF stopped (lack of efficacy) |
| 4 | F | Articular | 5 | 36 | Fever, polyarthritis, fatigue | Etanercept 25 mg ×2/week | PDN 20 mg/day | Partial response | Oligoarthritis | 43 months. Anti-TNF ongoing |
| 5 | F | Articular | 17 | 29 | Polyarthritis | Infliximab 3 mg/kg | MTX | Failure | Polyarthritis | 1 month. Anti-TNF stopped (side effects) |
| 6 | F | Systemic | 2 | 74 | Fever, arthralgia, rash | Infliximab 5 mg/kg | PDN 20 mg/day MTX 15 mg/week | Partial response | Rash, arthralgia | 1 month. Anti-TNF stopped (side effects) |
| 7 | M | Articular | 17 | 28 | Fever, polyarthritis, myalgia | Infliximab 3 mg/kg | PDN 40 mg/day MTX 7.5 mg/week | Failure | Fever, arthritis, myalgia Polyarthritis, myalgia | 2 months. Anti-TNF stopped (side effects) |
| Rash | Etanercept 25 mg ×2/week | PDN 40 mg/day MTX 7.5 mg/week | Partial response | Rash, arthralgia | 1 month. Anti-TNF stopped (side effects) | |||||
| 8 | F | Articular | 6 | 61 | Polyarthritis, rash | Infliximab 3 mg/kg | PDN 10 mg/day MTX 17.5 mg/week | Remission | None | 44 months. Anti-TNF ongoing |
| 9 | F | Articular | 4 | 44 | Polyarthritis | Infliximab 3 mg/kg | PDN 50 mg/day MTX 15 mg/week | Partial response | Few arthritis | 34 months. Anti-TNF ongoing |
| 10 | F | Systemic | 2 | 73 | Fever, arthralgia, fatigue | Infliximab 3 mg/kg | PDN MTX 15 mg/week | Partial response | Arthralgia, fatigue | 12 months. Anti-TNF stopped (lack of efficacy) |
| 11 | F | Articular | 21 | 32 | Fever, polyarthritis, rash | Etanercept | PDN 15 mg/day MTX 7.5 mg/week | Partial response | Few arthritis | 10 months. Anti-TNF stopped (lack of efficacy) |
| 25 mg ×2/week | ||||||||||
| Infliximab 3 mg/kg | PDN 12 mg/day MTX 7.5 mg/week | Partial response | Few arthritis | 7 months. Anti-TNF stopped (lack of efficacy) | ||||||
| 12 | M | Articular | 12 | 29 | Fever, polyarthritis, rash | Infliximab 3 mg/kg | MTX 15 mg/week | Remission | None | 12 months. Anti-TNF stopped(lack of efficacy) |
| 13 | F | Articular | 2 | 18 | Polyarthritis | Etanercept | PDN 10 mg/day | Partial response | Few arthritis | 35 months. Anti-TNF ongoing |
| Fatigue | 25 mg ×2/week | MTX 10 mg/week | ||||||||
| 14 | M | Articular | 3 | 25 | Polyarthritis, rash | Infliximab 3 mg/kg | PDN 10 mg/day | Remission | None | 16 months. Anti-TNF ongoing |
| MTX 15 mg/week | ||||||||||
| 15 | F | Articular | 12 | 29 | Fever, arthralgia | Infliximab 3 mg/kg | PDN 5 mg/day MTX 12.5 mg/week | Remission | None | 36 months. Anti-TNF ongoing |
| 16 | F | Systemic | 14 | 37 | Fever, arthralgia, rash | Infliximab 3 mg/kg | PDN 20 mg/day AZA 150 mg/day | Partial response | Arthralgia, rash | 9 months. Anti-TNF stopped (lack of efficacy) |
| 17 | M | Articular | 5 | 18 | Fever, polyarthritis | Etanercept 25 mg ×2/week | PDN 20 mg/day | Partial response | Few arthritis | 9 months. Anti-TNF stopped (lack of efficacy) |
| Infliximab 3 mg/kg | PDN 15–20 mg/day MT X 7.5 mg/week | Partial response | Few arthritis | 3 months. Anti-TNF ongoing (lack of efficacy) | ||||||
| 18 | F | Articular | 11 | 46 | Fever, polyarthritis | Etanercept 25 mg ×2/week | PDN 15– 20 mg/day MTX 20 mg/week | Partial response | Few arthritis | 6 months. Anti-TNF ongoing |
| 19 | F | Systemic | 7 | 32 | Fever, polyarthritis, rash | Etanercept 25 mg ×2/week | PDN 15– 20 mg/day | Failure | Fever, arthritis, rash | 3 months, Anti-TNF stopped (lack of efficacy) |
| Sore throat | Infliximab 3 mg/kg | PDN 15– 20 mg/day | Partial response | Few arthritis, rash | 4 months. Anti-TNF stopped (other: serious burn) | |||||
| 20 | F | Articular | 15 | 60 | Fever, polyarthritis, rash | Infliximab 3 mg/kg | PDN 45 mg/day MTX 17.5 mg/week | Partial response | Few arthritis | 8 months. Anti-TNF ongoing |