Sensitivity of CCP/RF isotypes according to disease duration, radiological damage, and disease activity
| All | IgG-RF | IgA-RF | IgM-RF | CCP | |
|---|---|---|---|---|---|
| Values are n (%). | |||||
| *Disease duration. | |||||
| ACR, American College of Rheumatology disease activity score; CCP, anti-cyclic citrullinated peptide antibodies; Ig, immunoglobulin; Larsen, Larsen radiological score21; RA, rheumatoid arthritis; RF, rheumatoid factor. | |||||
| All RA patients | 295 (100) | 129 (43.7) | 150 (50.8) | 196 (66.4) | 190 (64.4) |
| <1 year* | 97 (32.9) | 34 (35.0) | 35 (36.1) | 55 (56.7) | 53 (54.7) |
| 1–5 years* | 59 (20.0) | 31 (52.5) | 38 (64.4) | 41 (69.5) | 40 (67.8) |
| >5 years* | 139 (47.1) | 64 (46.0) | 77 (55.4) | 100 (71.9) | 97 (69.7) |
| Larsen 0–1 | 109 (36.9) | 44 (40.4) | 50 (45.3) | 73 (67.0) | 59 (54.1) |
| Larsen 2–3 | 115 (39.0) | 59 (44.3) | 65 (56.5) | 75 (65.2) | 74 (64.3) |
| Larsen 4–5 | 71 (24.1) | 34 (47.9) | 35 (48.3) | 48 (67.6) | 57 (80.3) |
| ACR <35 | 130 (44.1) | 48 (36.9) | 58 (44.6) | 85 (65.4) | 76 (58.5) |
| ACR 35–65 | 106 (35.9) | 47 (44.3) | 50 (47.2) | 68 (64.2) | 66 (62.3) |
| ACR >65 | 59 (20) | 34 (57.6) | 42 (71.2) | 43 (72.9) | 48 (81.4) |