Reported chromosomal abnormalities seen in specific subtypes of NHL
| Translocation | Associated histology | Oncogene affected | Molecular events | Comments |
|---|---|---|---|---|
| t(3;16) (q27;p11) | Diffuse large B cell (DLBC) | bcl-6 | Lymphocyte proliferation | 16–35% of DLBC and ⩽13% of follicular NHL have bcl-6 translocation 15% of DLBC have bcl-1 translocation Mutations of the p53 suppressor gene may also be seen in DLBC (especially those that transformed from FL) |
| t(14;18) (q32;q21) | Follicular (FL) | bcl-2 | Apoptosis inhibition | 80–90% of FL, and 6–30% of DLBC have bcl-2 translocation (These DLBC may represent transformation from FL) |
| t(8:14) (q24:q32) | Burkitt’s | c-myc | Lymphocyte proliferation | Translocation of t(8:14) and others involving c-myc present to a lesser extent in DLBC (∼10%). |
| t(1;14) (p22;q32) | Marginal zone (MALT) | bcl-10 | Apoptosis inhibition | Another translocation, t(15;16) (p21,q21) in ∼25% of MALT |