Summary of the material and physical properties of the cancellous bone cores and concentrations of the IGF system components measured in extracts of bone sampled from the superior and inferior regions of femoral heads
| IGFBP-5 (ng/mg bone) | IGF-I (ng/mg bone) | IGF-II (ng/mg bone) | Apparent density (g/cm3) | Stiffness (MPa) | |||||
|---|---|---|---|---|---|---|---|---|---|
| Superior | Inferior | Superior | Inferior | Superior | Inferior | Superior | Inferior | Superior | Inferior |
| Data are presented as median values, ranges, and the number of subjects (n). Differences between the healthy controls and OA groups are indicated by *, and between regions by †. Levels of statistical significance are denoted by: a, p<0.05; b, p<0.005; c, p<0.001; d, p<0.0005; and e, p<0.0001. | |||||||||
| Healthy | |||||||||
| 0.73 | 0.95 | 0.06 | 0.06 | 0.21 | 0.21 | 0.62†c | 0.29 | 247†c | 51 |
| (0.14–1.10) | (0.18–1.90) | (0.02–0.11) | (0.04–0.09) | (0.05–0.41) | (0.12–0.34) | (0.40–1.01) | (0.20–0.57) | (69–548) | (37–167) |
| 10 | 11 | 10 | 11 | 10 | 11 | 11 | 11 | 11 | 11 |
| Primary OA | |||||||||
| 1.60*e | 1.54*b | 0.09 | 0.07 | 0.22 | 0.16 | 0.73†e | 0.43*a | 226†d | 58 |
| (0.75–3.79) | (0.70–2.96) | (0.03–0.24) | (0.02–0.18) | (0.11–0.31) | (0.09–0.32) | (0.44–1.07) | (0.27–0.75) | (40–598) | (8–298) |
| 18 | 17 | 18 | 17 | 18 | 17 | 21 | 19 | 21 | 19 |
| Secondary OA—Paget’s disease | |||||||||
| 2.44*a | 1.75*a | 0.06 | 0.05 | 0.23 | 0.20 | 0.66†a | 0.41 | 239 †b | 58 |
| (0.70–4.99) | (0.70–3.19) | (0.02–0.06) | (0.02–0.16) | (0.19–0.32) | (0.17–0.29) | (0.45–1.15) | (0.23–0.84) | (154–791) | (23–151) |
| 6 | 7 | 6 | 7 | 6 | 7 | 7 | 7 | 7 | 7 |
| Combined OA group | |||||||||
| 1.75*d | 1.54*b | 0.08 | 0.05 | 0.22†a | 0.18 | 0.68†e | 0.41*a | 239†e | 58 |
| (0.38–4.99) | (0.38–3.19) | (0.02–0.24) | (0.02–0.18) | (0.11–0.37) | (0.09–0.32) | (0.44–1.15) | (0.22–0.84) | (40–791) | (8–298) |
| 27 | 27 | 27 | 27 | 27 | 27 | 31 | 29 | 31 | 29 |