Table 2

Longitudinal controlled cohort studies included in the analysis

Ref	Author	NSAID	Dose	Indication	Treated group size	Control group size	Outcomes
p/d, person-day; p/y, person-year.
59	Kurata et al	Any	N/A	Gastrointestinal bleeding in patients with dyspepsia	282	263	GI-major
56	Allison et al	Any	N/A	Gastrointestinal ulcers	249	464	GI-major
51	Guess et al	Any	N/A	Fatal upper GI haemorrhage or perforation	134060 p/y	834051 p/y	GI-major
60	McMahon et al	Any	N/A	Upper GI haemorrhage and perforation	25700	24550	GI-major
53	Carson et al	Any	N/A	Upper tract bleeding	47136	44634	GI-major
55	Beardon et al	Any	N/A	Gastrointestinal events	Events per 1000 subjects	Events per 1000 subjects	GI-any
57	MacDonald et al	Any	N/A	Gastrointestinal toxicity	52293	73792	GI-major
							GI-minor
52	Bloom et al	Any	N/A	Gastrointestinal toxicity	33880	36200	GI-major
				Cost			GI-minor
61	Smalley et al	Any	N/A	Incidence of hospitalisations for peptic ulcer disease in elderly people	1000 p/y	1000 p/y	GI-major
58	Fries et al	Any	N/A	Serious GI events	1694	1053	GI-major
62	Garcia Rodriguez et al	Any	N/A	Hospitalisation for upper GI bleeding	700000		GI-major
63	Beard et al	Any	N/A	Hospitalisation for gastro-oesophageal bleeding	6095000 p/d	38006000	GI-major
13	Mamdani et al	Any	N/A	Upper GI tract bleeding	5291	100000	GI-major