Baseline values and changes after 6 weeks of treatment in the WOMAC score and MDHAQ pain and gastrointestinal distress visual analogue scales at the end of each treatment period in PACES clinical trials
| Period I | Period II | |||||
|---|---|---|---|---|---|---|
| Celecoxib (n = 181) | Acetaminophen (n = 171) | Placebo (n = 172) | Celecoxib (n = 229) | Acetaminophen (n = 178) | Placebo (n = 117) | |
| *This is the percentage of treatment mean change from treatment mean baseline, not mean percentage of individual change from baseline. | ||||||
| Values are the mean (SE) unless otherwise stated. | ||||||
| A. PACES-a | ||||||
| WOMAC target joint | ||||||
| Baseline | 48.6 (1.47) | 52.8 (1.52) | 50.3 (1.60) | 49.0 (1.49) | 47.5 (1.73) | 45.1 (2.15) |
| Change | −10.4 (1.54) | −8.4 (1.52) | −4.8 (1.66) | −8.6 (1.15) | −4.5 (1.17) | −3.6 (1.36) |
| % Change* | −21.4 | −15.9 | −9.5 | −17.6 | −9.5 | −8.0 |
| MDHAQ visual analogue pain scale | ||||||
| Baseline | 62.0 (1.11) | 67.5 (1.17) | 64.0 (1.16) | 56.8 (1.64) | 54.2 (1.91) | 55.1 (2.53) |
| Change | −19.0 (1.91) | −17.4 (1.99) | −10.5 (1.92) | −12.8 (1.56) | −5.9 (1.64) | −4.9 (2.20) |
| % Change* | −30.6 | −25.8 | −16.4 | −22.5 | −10.9 | −8.9 |
| MDHAQ visual analogue patient gastrointestinal distress scale | ||||||
| Baseline | 19.2 (1.71) | 21.2 (1.82) | 19.4 (1.75) | 23.3 (1.71) | 22.2 (1.87) | 18.5 (2.10) |
| Change | −0.9 (1.62) | 3.6 (1.91) | 2.2 (1.86) | −0.3 (1.34) | −2.2 (1.40) | 4.6 (2.50) |
| % Change* | −4.7 | +17.0 | +11.3 | −1.3 | −9.9 | +24.9 |
| (n = 189) | (n = 185) | (n = 182) | (n = 242) | (n = 190) | (n = 124) | |
| B. PACES-b | ||||||
| WOMAC target joint | ||||||
| Baseline | 52.0 (1.29) | 51.6 (1.27) | 52.5 (1.46) | 47.3 (1.47) | 47.7 (1.61) | 45.0 (1.83) |
| Change | −13.5 (1.36) | −8.4 (1.31) | −4.6 (1.49) | −10.0 (1.17) | −4.9 (1.12) | −2.4 (1.28) |
| % Change* | −26.0 | −16.3 | −8.8 | −21.2 | −10.3 | −5.3 |
| MDHAQ visual analogue pain scale | ||||||
| Baseline | 65.2 (1.08) | 64.6 (1.24) | 64.4 (1.15) | 55.8 (1.68) | 57.2 (1.81) | 54.3 (2.21) |
| Change | −21.8 (1.93) | −13.8 (1.74) | −7.6 (1.99) | −13.0 (1.62) | −8.7 (1.75) | −2.0 (2.14) |
| % Change* | −33.4 | −21.4 | −11.8 | −23.3 | −15.2 | −3.7 |
| MDHAQ visual analogue patient gastrointestinal distress scale | ||||||
| Baseline | 22.2 (1.78) | 18.7 (1.56) | 21.1 (1.87) | 25.4 (1.75) | 23.7 (1.84) | 22.0 (2.39) |
| Change | −1.1 (1.56) | 5.0 (1.83) | 2.4 (1.76) | −3.0 (1.61) | 2.4 (1.65) | −0.9 (1.72) |
| % Change* | −5.0 | +26.7 | +11.4 | −11.8 | +10.1 | −4.1 |